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KMID : 0380020160310030178
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Korean Journal of Biotechnology and Bioengineering
2016 Volume.31 No. 3 p.178 ~ p.185
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Skin Volume Augmentation and Anti-wrinkle Effects of Tribulus terrestris Fruit Extract
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Kim Mi-Jin
Jung Taek-Kyu
Park Hyun-Chul
Yoon Kyung-Sup
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Abstract
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Aging of the face is mainly related to the features that are sagging or loss of elasticity of the skin by reducing the volume around the eyes or cheek. Intrinsic aging can be seen to cause thinner dermis, reduction of extracellular matrix and subcutaneous fat. This study was carried out to investigate the skin volume augmentation and anti-wrinkle effects of Tribulus terrestris fruit extract. Skin anti-aging effect of Tribulus terrestris fruit extract was evaluated by using lipid accumulation, expressin of type I procollagen and elastin in preadipocytes and human dermal fibroblasts. Tribulus terrestris fruit extract augmented preadipocytes differentiation about 56% at 100 μg/mL. The type I procollagen and elastin were increased about 35% and 25% by treatment 20% Tribulus terrestris fruit extract, respectively. The clinical study also showed that skin sagging, skin elasticity, and dermal density improved without adverse effect following 4 week application of cream containing 2% Tribulus terrestris fruit extract. We suggest that Tribulus terrestris fruit extract can have the good possibility as skin volume augmenting, skin elasticity and wrinkle improving agent.
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KEYWORD
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Anti-wrinkle, Elasticity, Skin volume, Subcutaneous fat, Tribulus terrestris fruit extract
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